Wenhui Zhou

MD-PhD Trainee

B.S University of California, Davis

Basal-like breast cancer (BLBC) is an aggressive breast cancer subtype for which there is currently no effective targeted treatment. Our lab previously identified the transcriptional repressor Slug is frequently overexpressed in BLBC, and Slug is an important regulator of luminal differentiation. I carried out a chemical screen to identify potential homeostatic regulator(s) of Slug protein. In doing so, my goal is to pinpoint druggable regulators for developing rational therapeutic strategies to molecularly dampen Slug hyperactivity, and ultimately improve our abilities to treat and improve outcome of patients diagnosed with BLBC.