Research Articles

  1. Liu Z, Quinn KP, Speroni L, Arendt L, Kuperwasser C, Sonnenschein C, Soto A, Georgakoudi, I. Rapid three-dimensional quantification of voxel-wise collagen fiber orientation. Biomedical Optics Express . 6 (7), 2294-2310, 2015. [PubMed]
  2. Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, Dake B, Glover E, Richardson A, Cowan J, Toland AE, Ravichandran K, Riethman H, Naber SP, Näär AM, Blasco MA, Hinds PW, Kuperwasser C. Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence. Nature Commun. Jun 24;6:7505, 2015. [PubMed]
  3. Schubert SM, Arendt LM, Zhou W, Baig S, Walter SR, Buchsbaum RJ, Kuperwasser C, Walt DR. 8;5:11034. doi: 10.1038/srep11034.
    Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring. Sci Rep . Jun 8;5:11034, 2015. [PubMed]
  4. Mazumdar S, Arendt LM, Phillips S, Sedic M, Kuperwasser C, Gill G. CoREST1 Promotes Tumor Formation and Tumor Stroma Interactions in a Mouse Model of Breast Cancer. PLoS One. 10(3):e0121281. 2015. [PubMed]
  5. Arendt LM, St. Laurent J, Wronski A, Caballero S., Lyle SR, Naber SP, Kuperwasser C. Human breast progenitor cells numbers are regulated by WNT and TBX3. PlosOne. Oct 28;9(10):e111442, 2014. [PubMed]
  6. Arendt LM ,Keller PJ, Skibinski A, Goncalves K, Naber SP, Buchsbaum RJ, Gilmore H, Come SE, Kuperwasser C. Anatomical localization of progenitor cells in human breast tissue reveals enrichment of uncommitted cells within immature lobules. Breast Cancer Research. Oct 15;16(5):453, 2014. [PubMed]
  7. Phillips S, Prat A, Sedic M, Proia T, Wronski A, Mazumdar S, Skibinski A, Shirley SH, Perou CM, Gill G, Gupta PB, Kuperwasser C. Cell-state transitions regulated by Slug are critical for tissue regeneration and tumor initiation. Stem Cell Reports. 2(5):633-47, 2014. [PubMed]
  8. Kottakis F, Foltopoulou P, Sanidas I, Keller P, Wronski A, Dake BT, Ezell SA, Shen Z, Naber SP, Hinds PW, McNiel E, Kuperwasser C, Tsichlis PN. NDY1/KDM2B Functions as a Master Regulator of Polycomb Complexes and Controls Self-Renewal of Breast Cancer Stem Cells. Cancer Res. Jul 15;74(14):3935-46, 2014. [PubMed]
  9. Skibinski A, Breindel JL, Prat A, Galván P, Smith E, Rolfs A, Gupta PB, LaBaer J, Kuperwasser C. The Hippo transducer TAZ interacts with the SWI/SNF complex to regulate breast epithelial lineage commitment. Cell Rep. Mar 27;6(6):1059-72, 2014 [PubMed]
  10. McCready J, Arendt LM, Glover E, Iyer V, Briendel JL, Lyle SR, Naber SP, Jay DG, Kuperwasser C. Pregnancy-associated breast cancers are driven by differences in adipose stromal cells present during lactation. Breast Cancer Res. Jan 9;16(1):R2, 2014 [PubMed]
  11. McLaughlin SK, Olsen SN, Dake B, De Raedt T, Lim E, Bronson RT, Beroukhim R, Polyak K, Brown M, Kuperwasser C, Cichowski K. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. Cancer Cell. Sep 9;24(3):365-78, 2013. [PubMed]
  12. Arendt LM, McCready J, Keller PJ, Baker DD, Naber SP, Seewaldt V, Kuperwasser C. Obesity promotes breast cancer by CCL2-mediated macrophage recruitment and angiogenesis. Cancer Research. Oct 1;73(19):6080-93, 2013. [PubMed]
  13. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. Apr;5(4):488-508, 2013. [PubMed] [PDF]
  14. Zhu C, Gupta A, Hall VL, Rayla AL, Christensen RG, Dake B, Lakshmanan A, Kuperwasser C, Stormo GD, Wolfe SA. Using Defined Finger-Finger Interfaces as Units of Assembly for Constructing Zinc Finger Nucleases. Nucleic Acids Res. Feb 1;41(4):2455-65, 2013. [PubMed] [PDF]
  15. Brown N, Jeselsohn R, Bihani T, Hu MG, Folotpoulu P, Kuperwasser C, Hinds PW. Cyclin D1 activity regulates autophagy and senescence in the mammary epithelium. Cancer Res. Dec 15;72(24):6477-89, 2012. [PubMed]
  16. Mueller KL, Madden JM, Zoratti GL, Kuperwasser C, List K, Boerner JL. Fibroblast-secreted hepatocyte growth factor mediates epidermal growth factor receptor tyrosine kinase inhibitor resistance in triple-negative breast cancers through paracrine activation of Met. Breast Cancer Res. Jul 12;14(4):R104, 2012. [PubMed]
  17. Iyer V, Klebba I, McCready J, Arendt LM, Betancur-Boissel M, Wu MF, Zhang X, Lewis MT, Kuperwasser C Estrogen promotes ER-negative tumor growth and angiogenesis through mobilization of bone marrow-derived monocytes. Cancer Res. Jun 1;72(11):2705-13, 2012. [PubMed] [PDF]
  18. Rudnick JA, Arendt LM, Klebba I, Hinds JW, Iyer V, Gupta PB, Naber SP, Kuperwasser C. Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells. PlosOne. 6(9):e24605, 2011. [PubMed] [PDF]
  19. Keller PJ, Arendt LM, Skibinski A, Logvinenko T, Klebba I, Dong S, Gilmore H, Schnitt S, Naber SP, Garlick JA, Kuperwasser C. Defining the cellular precursors to human breast cancer. Proc Natl Acad Sci. Feb 21;109(8):2772-7, 2012. (*Faculty of 1000 recommended) [PubMed] [PDF] [PDF (Supplemental Material)]
  20. Gupta PB, Fillmore CM, Kuperwasser C, Lander ES. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell. 146(4):633-44, 2011. (*Commentary in Nat Rev Cancer. 2011;11(10):691). (*Faculty of 1000 recommended) [PubMed]
  21. Chaffer CL, Brueckmann I, Scheel C, Kaestli AJ, Wiggins PA, Rodrigues LO, Brooks M, Reinhardt F, Su Y, Polyak K, Arendt LM, Kuperwasser C, Bierie B, Weinberg RA. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci. 108(19):7950-5, 2011. [PubMed]
  22. Hwu D, Boutrus S, Greiner C, DiMeo T, Kuperwasser C, Georgakoudi I. Assessment of the role of circulating breast cancer cells in tumor formation and metastatic potential using in vivo flow cytometry. J Biomed Opt. Apr;16(4):040501, 2011. [PubMed]
  23. Proia TA, Keller PJ, Gupta PB, Klebba I, Gilmore H, Tung N, Naber SP, Schnitt S, Lander ES, Kuperwasser C. Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell. Feb 4;8(2):149-63, 2011. (*Commentary in Nat Rev Cancer. 2011 Mar;11(3):158 and in Cell Stem Cell. 2011 Feb 4;8(2):126-7) [PubMed] [PDF]
  24. Fillmore CM, Gupta PB, Rudnick JA, Caballero S, Keller PJ, Lander ES, Kuperwasser C. Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. Dec 14;107(50):21737-42, 2010. [PubMed]
  25. Keller PJ, Lin AF, Arendt LM, Klebba I, Jones AD, Rudnick JA, Dimeo TA, Gilmore H, Jefferson DM, Graham RA, Naber SP, Schnitt S, Kuperwasser C. Mapping the cellular and molecular heterogeneity of normal and malignant breast tissues and cultured cell lines. Breast Cancer Res. 12(5):R87, 2010. [PubMed]
  26. Xu K, Rajagopal S, Klebba I, Dong S, Ji Y, Liu J,, Kuperwasser C, Garlick JA, Naber SP, Buchsbaum RJ. The role of fibroblast Tiam1 in tumor cell invasion and metastasis. Oncogene. Dec 16;29(50):6533-42, 2010. [PubMed]
  27. Jeselsohn R, Brown NE, Arendt L, Klebba I, Hu MG, Kuperwasser C, Hinds PW. Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis. Cancer Cell. Jan 19;17(1):65-76, 2010. [PubMed]
  28. Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, Lander ES. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. Aug 21;138(4):645-59, 2009. (* Commentary in   2009 Aug 21;138(4):623-5.) (*Faculty of 1000 recommended) [PubMed]
  29. DiMeo TA, Anderson K, Fen C, Padkhe P, Naber S, Perou C, Kuperwasser C. A novel lung metastasis signature links wnt signaling with cancer cell self-renewal and the epithelial-mesenchymal transition in basal-like breast cancer. Cancer Research. Jul 1;69(13):5364-73, 2009. [PubMed]
  30. Wu M, Jung L, Cooper AB, Fleet C, Chen C, Breault L, Clark K, Cai Z, Vincent S, Bottega S, Shen Q, Richardson A, Bosenburg M, Naber SP, DePinho RA, Kuperwasser C, Robinson MO. Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice. Proc Natl Acad Sci. Apr 28;106(17):7022-7, 2009. (*Commentary in   Proc Natl Acad Sci U S A. 2004 April 6; 101(14): 4723–4724.) [PubMed]
  31. Maroulakou IG, Oemler W, Naber SP , Klebba I, Kuperwasser C , Tsichlis PN. Distinct roles of the three Akt isoforms in lactogenic differentiation and involution J Cell Physiol. Nov;217(2):468-77, 2008. [PubMed]
  32. Fillmore CM, Kuperwasser C. Human breast cancer cell lines contain stem-like cells with the capacity to self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res. Mar 26;10(2):R25, 2008. [PubMed]
  33. Paulson KE, Rieger-Christ K, McDevitt MA, Kuperwasser C, Kim J, Unanue VE, Zhang X, Hu M, Ruthazer R, Berasi SP, Huang C, Giri D, Kaufman S, Dugan JM, Blum J, Netto G, Wazer DE, Summerhayes IC, Yee AS. Alterations of the HBP1 transcriptional repressor are associated with invasive breast cancer. Cancer Res. Jul 1;67(13):6136-45, 2007. [PubMed]
  34. Phung TL, Eyiah-Mensah G, O’Donnell RK, Bieniek R, Shechter S, Walsh K, Kuperwasser C, Benjamin LE. Endothelial Akt signaling is rate limiting for rapamycin inhibition of mouse mammary tumor progression. Cancer Res. Jun 1;67(11):5070-5, 2007. [PubMed]
  35. Boutrus S, Greiner C, Hwu D, Chan M, Kuperwasser C, Lin CP, Georgakoudi I. A Portable Two-Color In Vivo Flow Cytometer for Real-Time Detection of Fluorescently-Labeled Circulating Cells. J Biomed Opt. Mar-Apr;12(2):020507, 2007. [PubMed]
  36. Gupta PB, Proia D, Cingoz O, Weremowicz J, Naber SP, Weinberg RA, Kuperwasser C. Systemic stromal effects of estrogen promotes the growth of estrogen receptor-negative cancers. Cancer Res. Mar 1;67(5):2062-71, 2007. [PubMed]
  37. Proia DA, Kuperwasser C. Reconstruction of human mammary tissues in a mouse model. Nature Protoc. 1(1): 206-214, 2006. [PubMed]
  38. Gupta PB, Kuperwasser C, Brunet JP, Ramaswamy S, Kuo WL, Gray JW, Naber SP, Weinberg RA. The melanocyte differentiation program predisposes for metastasis following neoplastic transformation. Nat Genet. Oct;37(10):1047-54, 2005. (* Faculty of 1000 nominated) [PubMed]
  39. Kuperwasser C, Dessain S, Bierbaum BE, Garnet D, Sperandio K, Gauvin GP, Naber SP, Weinberg RA, Rosenblatt M. A mouse model of human breast cancer metastasis to human bone. Cancer Res. Jul 15;65(14):6130-8, 2005. [PubMed]
  40. Kuperwasser C, Chavarria T, Wu M, Magrane G, Gray JW, Carey L, Richardson A, Weinberg RA. Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A. Apr 6;101(14):4966-71, 2004. (* Commentary in Proc Natl Acad Sci U S A. 2004 Apr 6;101(14):4723-4.) [PubMed]
  41. Kuperwasser C, Hurlbut GD, Kittrell FS, Dickinson ES, Laucirica R, Medina D, Naber SP, Jerry DJ. Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome. Am J Pathol. Dec;157(6):2151-9, 2000. [PubMed]
  42. Kuperwasser C, Pinkas J, Hurlbut GD, Naber SP, Jerry DJ. Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment. Cancer Res. May 15;60(10):2723-9, 2000. [PubMed]
  43. Jerry DJ, Kittrell FS, Kuperwasser C, Laucirica R, Dickinson ES, Bonilla PJ, Butel JS, Medina D. A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development. Oncogene. Feb 21;19(8):1052-8, 2000. [PubMed]
  44. Jerry DJ, Pinkas J, Kuperwasser C, Dickinson ES, Naber SP. Regulation of p53 and its targets during involution of the mammary gland. J Mammary Gland Biol Neoplasia. Apr;4(2):177-81, 1999. [PubMed]
  45. Jerry DJ, Kuperwasser C, Downing SR, Pinkas J, He C, Dickinson E, Marconi S, Naber SP. Delayed involution of the mammary epithelium in BALB/c-p53null mice. Oncogene. 17: 2305-2312, 1998. [PubMed]
  46. Medina D, Stephens LC, Bonilla PJ, Hollmann CA, Schwahn D, Kuperwasser C, Jerry DJ, Butel JS, Meyn RE. Radiation-induced tumorigenesis in preneoplastic mouse mammary glands in vivo: significance of p53 status and apoptosis. Mol Carcinogenesis. 22: 199-207, 1998. [PubMed]

Reviews and Book Chapters

  1. Arendt LM, Kuperwasser C. Working stiff: How obesity boots cancer risk. Sci Transl Med. 2015 Aug 19;7(301):301fs34, 2015. [PubMed]
  2. Arendt LM, Kuperwasser C. Form and Function: how Estrogen and Progesterone Regulate the Mammary Epithelial Hierarchy. J Mammary Gland Biol Neoplasia. Jun;20(1-2):9-25, 2015. [PubMed]
  3. Wronski A, Arendt L, Kuperwasser C. Humanization of the Mouse Mammary Gland. Mammary Stem Cells Methods in Molecular Biology. Springer Science & Business Media LLC New York, 2015. [PDF]
  4. Skibinski A, Kuperwasser C. The origin of breast tumor heterogeneity. Oncogene Feb 23, 2015. [Epub ahead of print] [PubMed]
  5. Phillips S, Kuperwasser C. SLUG: Critical regulator of epithelial cell identity in breast development and cancer. Cell Adh Migr. 8(6):578-87, 2014. [PubMed]
  6. Keller PJ, Arendt LM, Kuperwasser C. Human mammary epithelial stem/progentior cells. Stem Cell Handbook. 2nd Edition Springer US 2012.
  7. Rudnick JA, Kuperwasser C. Stromal biomarkers in breast cancer development and progression. Clin Exp Metastasis. Oct;29(7):663-72, 2012. [PubMed] [PDF]
  8. Keller PJ, Arendt LM, Kuperwasser C. Stem cell maintenance of the mammary gland: it takes two. Cell Stem Cell. Dec 2;9(6):496-7, 2011. [PubMed] [PDF]
  9. Kuperwasser C. The tumor stromal microenvironment as modulator of malignant behavior. J Mammary Gland Biol Neoplasia. Dec;15(4):377-9, 2010. [PubMed] [PDF]
  10. McCready J, Arendt LM, Rudnick JA, Kuperwasser C. The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis. Breast Cancer Res. Jun 17;12(3):205, 2010. [PubMed]
  11. Arendt LM, Rudnick JA, Keller PJ, Kuperwasser C. Stroma in Breast Development and Disease. Semin Cell Dev Biol. Feb;21(1):11-8, 2010. [PubMed]
  12. Fillmore C, Kuperwasser C. Human breast cancer stem cell markers CD44 and CD24: enriching for cells with functional properties in mice or in man? Breast Cancer Res. 9(3):303, 2007. [PubMed]
  13. Gupta PB, Kuperwasser C. Contributions of estrogen to ER-negative breast tumor growth. J Steroid Biochem Mol Biol. Dec;102(1-5):71-8, 2006. [PubMed]
  14. DiMeo TA, Kuperwasser C. The evolving paradigm of tissue-specific metastasis. Breast Cancer Res. 8(1):301, 2005. [PubMed]
  15. Proia DA, Kuperwasser C. Stroma: tumor agonist or antagonist. Cell Cycle. Aug;4(8):1022-5, 2005. [PubMed]
  16. Gupta PB, Kuperwasser C. Disease models of cancer: Breast cancer. Drug Discovery Today. 1: 9-16, 2004. [PDF]