How “the cell-of-origin” influences the genetic and epigenetic events of breast cancer diversity and heterogeneity

Recent work from the Kuperwasser Lab has shown that the differentiation state of the cell-of-origin determines the type of cancer will eventually form. Other recent findings have also provided strong molecular evidence supporting the concept that haploinsufficiency for genes in may be associated with features of malignancy. Using these insights, Kuperwasser Lab is employing various genomic, proteomic and chemical platforms developed by various members of the Raymond and Beverly Sackler Convergence Lab to study the following:

• Identification of novel breast cancer drivers
• Identification of novel drivers of metastasis
• Identification of networks that control cell fate decision and differentiation
• Determine how the differentiation state of the cell of origin determines the genetic landscape of a cancer