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How mutations reprogram cell identity

Women with mutations in their BRCA1 genes are more likely than others to develop basal subtype breast cancer, but why this is, have remained unclear. Findings from the Convergence lab showed that even non-cancerous cells with these mutations express, or turn on, different genes, look different under a microscope and behave differently when they divide […]

Kayla Gross

Our lab focuses on investigating the molecular mechanisms that drive normal breast development and how these processes become disrupted in cancerous tissue. More specifically, we are interested in the role of stem and progenitor cells in both normal and carcinogenic development, especially the molecular drivers of breast epithelial differentiation. Previous work recently established the transcription […]

Jessica Elman

Our lab has shown that lineage-committed mammary epithelial cells can have bipotent character by stimulating luminal cells to adopt a basal phenotype. My project focuses on elucidating whether the reverse of this phenomenon can be induced, namely I aim to study whether basal cells can acquire a luminal phenotype.

Andrew DeCastro, PhD

Raymond and Beverly Sackler Fellow Breast tumors and other solid cancers do not exist in a vacuum and is a disease composed not only of cancer cells, but also the surrounding stromal cells making up the tumor microenvironment. My research interests are focused on the role of the surrounding fibroblasts in modulating the rigidity of […]